Table 1.
Cohort Characteristics by Phenotype
| Triple Negative | ER+ and/or PR +, HER2− | HER2 + | Total | P-value* | ||
|---|---|---|---|---|---|---|
| Age | <50 | 8,124 (22.3) | 48,458 (17.7) | 10,391 (25.3) | 66,973 (19.1) | <0.001 |
| 50–59 | 9,585 (26.3) | 65,305 (23.9) | 11,589 (28.2) | 86,479 (24.6) | ||
| 60–69 | 9,687 (26.5) | 80,324 (29.4) | 10,333 (25.2) | 100,344 (28.6) | ||
| ≥70 | 9,109 (25.0) | 79,434 (29.0) | 8,748 (21.3) | 97,291 (27.7) | ||
| Race | White | 27,808 (76.2) | 237,228 (86.7) | 33,863 (82.5) | 298,899 (85.1) | <0.001 |
| Black | 7,127 (19.5) | 22,920 (8.4) | 4,671 (11.4) | 34,718 (9.9) | ||
| Asian | 991 (2.7) | 8,581 (3.1) | 1,733 (4.2) | 11,305 (3.2) | ||
| Other/Unknown | 579 (1.6) | 4,792 (1.8) | 794 (1.9) | 6,165 (1.8) | ||
| Hispanic | No | 33,397 (91.5) | 251,757 (92.0) | 37,387 (91.1) | 322,541 (91.9) | <0.001 |
| Yes | 1,857 (5.1) | 12,538 (4.6) | 2,344 (5.7) | 16,739 (4.8) | ||
| Unknown | 1,251 (3.4) | 9,226 (3.4) | 1,330 (3.2) | 11,807 (3.4) | ||
| Insurance Status | Medicaid | 2,715 (7.4) | 14,345 (5.2) | 2,982 (7.3) | 20,042 (5.7) | <0.001 |
| Medicare | 12,999 (35.6) | 108,774 (39.8) | 12,761 (31.1) | 134,534 (38.3) | ||
| Not Insured | 804 (2.2) | 4,316 (1.6) | 934 (2.3) | 6,054 (1.7) | ||
| Other Government | 423 (1.2) | 2,756 (1.0) | 446 (1.1) | 3,625 (1.0) | ||
| Private Insurance/Managed Care | 19,137 (52.4) | 140,428 (51.3) | 23,430 (57.1) | 182,995 (52.1) | ||
| Unknown | 427 (1.2) | 2,902 (1.1) | 508 (1.2) | 3,837 (1.1) | ||
| Education | ≥ 21% | 6,173 (16.9) | 35,322 (12.9) | 6,237 (15.2) | 47,732 (13.6) | <0.001 |
| 13% - 20.9% | 9,363 (25.6) | 62,778 (23.0) | 10,063 (24.5) | 82,204 (23.4) | ||
| 7%−12.9% | 11,903 (32.6) | 91,987 (33.6) | 13,500 (32.9) | 117,390 (33.4) | ||
| < 7% | 8,991 (24.6) | 82,939 (30.3) | 11,171 (27.2) | 103,101 (29.4) | ||
| Missing | 75 (0.2) | 495 (0.2) | 90 (0.2) | 660 (0.2) | ||
| Income | <$38,000 | 6,555 (18.0) | 37,127 (13.6) | 6,356 (15.5) | 50,038 (14.3) | <0.001 |
| $38,000 - $47,999 | 8,263 (22.6) | 57,696 (21.1) | 8,854 (21.6) | 74,813 (21.3) | ||
| $48,000 - $62,999 | 9,800 (26.8) | 73,943 (27.0) | 11,137 (27.1) | 94,880 (27.0) | ||
| $63,000 + | 11,800 (32.3) | 104,168 (38.1) | 14,608 (35.6) | 130,576 (37.2) | ||
| Missing | 87 (0.2) | 587 (0.2) | 106 (0.3) | 780 (0.2) | ||
| Setting | Large metropolitan | 18,958 (51.9) | 145,216 (53.1) | 21,666 (52.8) | 185,840 (52.9) | <0.001 |
| Small metropolitan | 11,318 (31.0) | 84,009 (30.7) | 12,484 (30.4) | 107,811 (30.7) | ||
| Suburban | 3,419 (9.4) | 23,586 (8.6) | 3,672 (8.9) | 30,677 (8.7) | ||
| Rural | 1,935 (5.3) | 13,694 (5.0) | 2,178 (5.3) | 17,807 (5.1) | ||
| Unknown | 875 (2.4) | 7,016 (2.6) | 1,061 (2.6) | 8,952 (2.5) | ||
| Miles to reporting facility | ≤10 | 19,948 (54.6) | 149,389 (54.6) | 21,938 (53.4) | 191,275 (54.5) | <0.001 |
| 11–20 | 8,600 (23.6) | 65,383 (23.9) | 9,968 (24.3) | 83,951 (23.9) | ||
| 21–40 | 4,640 (12.7) | 34,344 (12.6) | 5,364 (13.1) | 44,348 (12.6) | ||
| >40 | 3,180 (8.7) | 23,618 (8.6) | 3,637 (8.9) | 30,435 (8.7) | ||
| Unknown | 137 (0.4) | 787 (0.3) | 154 (0.4) | 1,078 (0.3) | ||
| Transition (new algorithm) | No | 18,073 (49.5) | 141,375 (51.7) | 20,316 (49.5) | 179,764 (51.2) | <0.001 |
| Yes | 11,090 (30.4) | 82,285 (30.1) | 12,514 (30.5) | 105,889 (30.2) | ||
| Unknown | 7,342 (20.1) | 49,861 (18.2) | 8,231 (20.0) | 65,434 (18.6) | ||
| Facility Volume | 1st quartile: 0–45 pts/year | 2,338 (6.4) | 15,951 (5.8) | 2,617 (6.4) | 20,906 (6.0) | <0.001 |
| 2nd quartile: 46–82 pts/year | 5,410 (14.8) | 37,598 (13.7) | 6,133 (14.9) | 49,141 (14.0) | ||
| 3rd quartile: 83–152 pts/year | 9,257 (25.4) | 67,027 (24.5) | 10,172 (24.8) | 86,456 (24.6) | ||
| 4th quartile: >152 pts/year | 19,500 (53.4) | 152,945 (55.9) | 22,139 (53.9) | 194,584 (55.4) | ||
| Year of diagnosis | 2010 | 6,899 (18.9) | 44,747 (16.4) | 7,233 (17.6) | 58,879 (16.8) | <0.001 |
| 2011 | 7,552 (20.7) | 51,301 (18.8) | 8,004 (19.5) | 66,857 (19.0) | ||
| 2012 | 7,532 (20.6) | 55,521 (20.3) | 8,297 (20.2) | 71,350 (20.3) | ||
| 2013 | 7,491 (20.5) | 59,954 (21.9) | 8,751 (21.3) | 76,196 (21.7) | ||
| 2014 | 7,031 (19.3) | 61,998 (22.7) | 8,776 (21.4) | 77,805 (22.2) | ||
| Charlson score | 0 | 29,608 (81.1) | 225,958 (82.6) | 34,416 (83.8) | 289,982 (82.6) | <0.001 |
| 1 | 5,490 (15.0) | 38,894 (14.2) | 5,436 (13.2) | 49,820 (14.2) | ||
| 2 | 1,086 (3.0) | 6,915 (2.5) | 946 (2.3) | 8,947 (2.5) | ||
| ≥3 | 321 (0.9) | 1,754 (0.6) | 263 (0.6) | 2,338 (0.7) | ||
| Histology | Ductal | 33,509 (91.8) | 239,127 (87.4) | 39,096 (95.2) | 311,732 (88.8) | <0.001 |
| Lobular | 382 (1.0) | 31,588 (11.5) | 1,339 (3.3) | 33,309 (9.5) | ||
| Other | 2,614 (7.2) | 2,806 (1.0) | 626 (1.5) | 6,046 (1.7) | ||
| Tumor Size | <10mm | 5,571 (15.3) | 68,993 (25.2) | 8,074 (19.7) | 82,638 (23.5) | <0.001 |
| 10–19mm | 12,906 (35.4) | 114,689 (41.9) | 14,587 (35.5) | 142,182 (40.5) | ||
| ≥20mm | 17,569 (48.1) | 86,789 (31.7) | 17,215 (41.9) | 121,573 (34.6) | ||
| Unknown | 459 (1.3) | 3,050 (1.1) | 1,185 (2.9) | 4,694 (1.3) | ||
| Grade/Differentiation | Well | 746 (2.0) | 84,099 (30.7) | 2,253 (5.5) | 87,098 (24.8) | <0.001 |
| Moderate | 6,035 (16.5) | 131,592 (48.1) | 14,290 (34.8) | 151,917 (43.3) | ||
| Poor | 27,769 (76.1) | 43,706 (16.0) | 21,991 (53.6) | 93,466 (26.6) | ||
| Undifferentiated/Anaplastic | 175 (0.5) | 264 (0.1) | 148 (0.4) | 587 (0.2) | ||
| Unknown | 1,780 (4.9) | 13,860 (5.1) | 2,379 (5.8) | 18,019 (5.1) | ||
| Analytic Stage | I | 18,100 (49.6) | 174,031 (63.6) | 21,344 (52.0) | 213,475 (60.8) | <0.001 |
| II | 15,472 (42.4) | 81,398 (29.8) | 15,117 (36.8) | 111,987 (31.9) | ||
| III | 2,933 (8.0) | 18,092 (6.6) | 4,600 (11.2) | 25,625 (7.3) | ||
| Surgery | Breast Conservation | 21,491 (58.9) | 177,485 (64.9) | 20,696 (50.4) | 219,672 (62.6) | <0.001 |
| Mastectomy | 10,236 (28.0) | 57,339 (21.0) | 12,494 (30.4) | 80,069 (22.8) | ||
| Mastectomy with Reconstruction | 4,778 (13.1) | 38,697 (14.1) | 7,871 (19.2) | 51,346 (14.6) | ||
| Chemotherapy | Yes | 27,145 (74.4) | 72,160 (26.4) | 30,380 (74.0) | 129,685 (36.9) | <0.001 |
| No | 9,360 (25.6) | 201,361 (73.6) | 10,681 (26.0) | 221,402 (63.1) | ||
| Radiation | Yes | 22,660 (62.1) | 177,546 (64.9) | 23,845 (58.1) | 224,051 (63.8) | <0.001 |
| No | 13,845 (37.9) | 95,975 (35.1) | 17,216 (41.9) | 127,036 (36.2) | ||
| Endocrine therapy | Yes | 1,005 (2.8) | 236,233 (86.4) | 25,494 (62.1) | 262,732 (74.8) | <0.001 |
| No | 35,500 (97.2) | 37,288 (13.6) | 15,567 (37.9) | 88,355 (25.2) | ||
| Immunotherapy | Yes | 204 (0.6) | 992 (0.4) | 11,431 (27.8) | 12,627 (3.6) | <0.001 |
| No | 36,301 (99.4) | 272,529 (99.6) | 29,630 (72.2) | 338,460 (96.4) | ||
| Nodes examined | 0–1 | 7,531 (20.6) | 67,945 (24.8) | 8,026 (19.5) | 83,502 (23.8) | <0.001 |
| 2 | 7,065 (19.4) | 58,560 (21.4) | 7,755 (18.9) | 73,380 (20.9) | ||
| 3–4 | 8,763 (24.0) | 65,677 (24.0) | 9,183 (22.4) | 83,623 (23.8) | ||
| ≥5 | 12,904 (35.3) | 79,839 (29.2) | 15,814 (38.5) | 108,557 (30.9) | ||
| Unknown | 242 (0.7) | 1,500 (0.5) | 283 (0.7) | 2,025 (0.6) | ||
| Nodes positive | 0 | 26,902 (73.7) | 197,054 (72.0) | 27,115 (66.0) | 251,071 (71.5) | <0.001 |
| ≥1 | 8,572 (23.5) | 66,301 (24.2) | 12,926 (31.5) | 87,799 (25.0) | ||
| No nodes examined | 944 (2.6) | 9,707 (3.5) | 928 (2.3) | 11,579 (3.3) | ||
| Unknown | 87 (0.2) | 459 (0.2) | 92 (0.2) | 638 (0.2) | ||
| *Chi-square test |