Table 2.
Odds Ratio Estimates | |||||
---|---|---|---|---|---|
Estimate | 95% Confidence Limits | P-value | |||
Phenotype | HER2+ | REF | |||
TN | 0.82 | 0.79 | 0.84 | <0.001 | |
HR+ | 1.01 | 0.98 | 1.03 | 0.625 | |
Age | <50 | REF | |||
50–59 | 0.98 | 0.96 | 1.00 | 0.047 | |
60–69 | 0.96 | 0.94 | 0.98 | 0.001 | |
≥ 70 | 0.84 | 0.81 | 0.86 | <0.001 | |
Race | White | REF | |||
Black | 1.71 | 1.67 | 1.76 | <0.001 | |
Asian | 1.03 | 0.99 | 1.07 | 0.183 | |
Other/Unknown | 1.11 | 1.05 | 1.17 | 0.002 | |
Hispanic | No | REF | |||
Yes | 1.3 | 1.26 | 1.35 | <0.001 | |
Unknown | 0.97 | 0.93 | 1.02 | 0.192 | |
Insurance | Private Insurance | REF | |||
Medicaid | 1.76 | 1.71 | 1.82 | <0.001 | |
Medicare | 1.12 | 1.09 | 1.14 | <0.001 | |
Other Government | 1.34 | 1.25 | 1.43 | <0.001 | |
Not Insured | 1.44 | 1.36 | 1.52 | <0.001 | |
Unknown | 1.13 | 1.05 | 1.21 | 0.001 | |
Education | ≥ 21% | REF | |||
13% - 20.9% | 0.96 | 0.93 | 0.98 | 0.002 | |
7%−12.9% | 0.92 | 0.89 | 0.95 | <0.001 | |
< 7% | 0.86 | 0.83 | 0.89 | <0.001 | |
Income | < $38,000 | REF | |||
$38,000 - $47,999 | 0.97 | 0.95 | 1.00 | 0.023 | |
$48,000 - $62,999 | 0.97 | 0.94 | 0.99 | 0.015 | |
$63,000 + | 0.90 | 0.87 | 0.94 | <0.001 | |
Setting | Large metropolitan | REF | |||
Small metropolitan | 0.95 | 0.92 | 0.98 | 0.001 | |
Suburban | 0.91 | 0.87 | 0.94 | <0.001 | |
Rural | 0.86 | 0.81 | 0.90 | <0.001 | |
Unknown | 0.99 | 0.94 | 1.04 | 0.670 | |
Facility Volume | 1st quartile: 0–45 pts/year | 0.73 | 0.64 | 0.82 | <0.001 |
2nd quartile: 46–82 pts/year | 0.78 | 0.70 | 0.88 | <0.001 | |
3rd quartile: 83–152 pts/year | 0.83 | 0.74 | 0.93 | 0.002 | |
4th quartile: >152 pts/year | REF | ||||
Distance (miles) | ≤ 10 | REF | |||
11–20 | 0.99 | 0.97 | 1.01 | 0.148 | |
21–40 | 0.98 | 0.95 | 01.0 | 0.035 | |
>40 | 1.04 | 1.00 | 1.07 | 0.044 | |
Unknown | 1.31 | 0.67 | 2.54 | 0.428 | |
Transition | No | REF | |||
Yes | 1.58 | 1.55 | 1.61 | <0.001 | |
Unknown | 0.97 | 0.95 | 0.99 | 0.003 | |
Year of Diagnosis | 2010 | 0.72 | 0.70 | 0.74 | <0.001 |
2011 | 0.76 | 0.75 | 0.78 | <0.001 | |
2012 | 0.83 | 0.81 | 0.85 | <0.001 | |
2013 | 0.92 | 0.90 | 0.93 | <0.001 | |
2014 | REF | ||||
Comorbidities | 0 | 0.70 | 0.64 | 0.76 | <.0001 |
1 | 0.79 | 0.72 | 0.85 | <0.001 | |
2 | 0.90 | 0.83 | 0.99 | 0.033 | |
≥3 | REF | ||||
Histology | Ductal | REF | |||
Lobular | 1.10 | 1.07 | 1.12 | <0.001 | |
Other | 1.00 | 0.95 | 1.05 | 0.914 | |
Grade | Well | REF | |||
Moderate | 0.98 | 0.96 | 1.00 | 0.014 | |
Poor | 0.86 | 0.84 | 0.88 | <0.001 | |
Undifferentiated/Anaplastic | 0.91 | 0.77 | 1.08 | 0.273 | |
Unknown | 0.99 | 0.95 | 1.02 | 0.522 | |
Tumor Size | <10mm | REF | |||
10–19mm | 0.98 | 0.96 | 0.99 | 0.008 | |
≥ 20mm | 0.93 | 0.91 | 0.96 | <0.001 | |
Unknown | 1.05 | 0.98 | 1.11 | 0.157 | |
Stage | I | 0.91 | 0.87 | 0.94 | <0.001 |
II | 0.94 | 0.91 | 0.97 | <0.001 | |
III | REF | ||||
Surgery Type | Breast Conservation | REF | |||
Mastectomy | 1.36 | 1.32 | 1.39 | <0.001 | |
Mastectomy with Reconstruction | 2.99 | 2.92 | 3.07 | <0.001 | |
Chemotherapy | No | REF | |||
Yes | 0.79 | 0.78 | 0.81 | <0.001 | |
Radiation | No | REF | |||
Yes | 0.83 | 0.82 | 0.85 | <0.001 | |
Endocrine therapy | No | REF | |||
Yes | 0.87 | 0.86 | 0.89 | <0.001 | |
Nodes examined | 0–1 | REF | |||
2 | 1.02 | 1.00 | 1.04 | 0.143 | |
3–4 | 1.00 | 0.98 | 1.03 | 0.672 | |
≥5 | 0.96 | 0.94 | 0.98 | 0.002 | |
Positive Nodes | 0 | REF | |||
≥1 | 1.13 | 1.1 | 1.16 | <0.001 | |
No nodes examined | 1.31 | 1.26 | 1.37 | <0.001 |
TN = Triple negative, HR+ = Hormone Receptor-Positive, HER2+ = HER2−enriched, REF=Referent