Table 3.

Multivariable model for predictors of Overall Survival. (See Table 4 for tests of interaction between phenotypes and effects of delay.)

		Hazard Ratio	95% Confidence Limits		p-value
Delay (per month)		1.10	1.08	1.13	<0.001
Phenotype	TN	REF	.	.	.
	HR+	0.78	0.75	0.82	<0.001
	HER2+	0.74	0.70	0.78	<0.001
Age	<50	REF	.	.	.
	50–59	1.13	1.07	1.19	<0.001
	60–69	1.36	1.29	1.44	<0.001
	≥70	2.59	2.43	2.76	<0.001
Race	White	REF	.	.	.
	Black	1.01	0.97	1.06	0.578
	Asian	0.57	0.52	0.64	<0.001
	Other/Unknown	0.78	0.68	0.89	0.002
Hispanic	No	REF	.	.	.
	Yes	0.63	0.57	0.70	<0.001
	Unknown	1.00	0.93	1.09	0.914
Insurance	Private Insurance/ Managed Care	REF	.	.	.
	Medicaid	1.53	1.43	1.63	<0.001
	Medicare	1.44	1.37	1.50	<0.001
	Other Government	1.16	0.99	1.37	0.072
	Not Insured	1.37	1.21	1.55	<0.001
	Unknown	1.21	1.06	1.39	0.006
Education	≥ 21%	REF	.	.	.
	13% - 20.9%	1.03	0.98	1.08	0.218
	7%−12.9%	1.02	0.97	1.08	0.446
	< 7%	0.95	0.89	1.01	0.145
	Missing	2.31	1.12	4.76	0.023
Income	< $38,000	REF	.	.	.
	$38,000 - $47,999	0.97	0.93	1.01	0.173
	$48,000 - $62,999	0.92	0.88	0.97	0.002
	$63,000 +	0.88	0.82	0.93	<0.001
	Missing	0.75	0.39	1.44	0.392
Setting	Large metropolitan	REF	.	.	.
	Small metropolitan	1.11	1.06	1.16	<0.001
	Suburban	1.10	1.04	1.18	0.002
	Rural	1.10	1.02	1.20	0.019
	unknown	1.01	0.92	1.10	0.845
Facility Volume	1st quartile: 0–45 pts/year	REF	.	.	.
	2nd quartile: 46–82 pts/year	0.89	0.83	0.95	0.005
	3rd quartile: 83–152 pts/year	0.82	0.77	0.87	<0.001
	4th quartile: >152 pts/year	0.76	0.71	0.81	<0.001
Distance (miles)	≤10	REF	.	.	.
	11–20	0.92	0.89	0.95	<0.001
	21–40	0.88	0.84	0.93	<0.001
	>40	0.82	0.77	0.88	<0.001
	Unknown	0.96	0.71	1.29	0.777
Transition	No	REF	.	.	.
	Yes	0.93	0.90	0.96	<0.001
	Unknown	0.96	0.92	1.01	0.088
Year of Diagnosis	2010	REF	.	.	.
	2011	1.06	1.02	1.11	0.001
	2012	1.08	1.03	1.12	0.001
	2013	1.13	1.07	1.18	<0.001
	2014	1.13	1.06	1.20	0.002
Charlson comorbidity score	0	REF	.	.	.
	1	1.47	1.42	1.52	<0.001
	2	2.09	1.97	2.21	<0.001
	≥3	3.03	2.77	3.32	<0.001
Histology	Ductal	REF	.	.	.
	Lobular	0.98	0.93	1.02	0.311
	Other	1.05	0.96	1.15	0.266
Grade	Well	REF	.	.	.
	Moderate	1.14	1.10	1.18	0.001
	Poor	1.70	1.62	1.78	<0.001
	Undifferentiated/Anaplastic	2.17	1.76	2.69	<0.001
	Unknown	1.29	1.19	1.40	<0.001
Tumor Size	<10mm	REF	.	.	.
	10–19mm	1.37	1.31	1.43	<0.001
	≥20mm	1.95	1.85	2.06	<0.001
	Unknown	1.10	0.95	1.26	0.203
Stage	I	REF	.	.	.
	II	1.28	1.22	1.34	<0.001
	III	2.86	2.67	3.05	<0.001
Surgery Type	Breast Conservation	REF	.	.	.
	Mastectomy	0.98	0.94	1.02	0.232
	Mastectomy with Reconstruction	0.58	0.54	0.61	<0.001
Chemotherapy	No	REF	.	.	.
	Yes	0.60	0.57	0.62	<0.001
Radiation	No	REF	.	.	.
	Yes	0.59	0.57	0.61	<0.001
Endocrine therapy	No	REF	.	.	.
	Yes	0.53	0.51	0.55	<0.001
Nodes Examined	0–1	REF	.	.	.
	2	0.92	0.88	0.97	0.007
	3–4	0.87	0.83	0.91	<0.001
	≥5	0.90	0.86	0.94	<0.001
	Unknown	1.11	0.91	1.34	0.304
Positive Nodes	0	REF	.	.	.
	≥1	1.56	1.50	1.63	<0.001
	No nodes examined	2.16	2.04	2.28	<0.001
	Unknown	1.65	1.28	2.15	0.002