Skip to main content
. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Exp Neurol. 2020 Mar 3;328:113272. doi: 10.1016/j.expneurol.2020.113272

Figure 8. Endoneurial microvessel wall thickening/ basement membrane duplication.

Figure 8.

Composite digital light photomicrographs of an axial section of a CIDP patient sural nerve biopsy (plastic embedded semi-thin axial section stained with Toluidine Blue and counterstained with Basic Fuchsin) showing endoneurial microvessel wall thickening (black arrows) at low magnification (A) and at higher magnification in another CIDP patient (B). These changes are also seen in a vasculitic neuropathy patient with chronic neuropathic pain (C). These changes are in contrast to thin walls seen in normal adult endoneurial microvessels (D). Composite digital ultramicrographs of the sural nerve biopsy from a CIDP patient (E and F) show endoneurial microvessel basement membrane duplication (white arrows). This is shown at higher magnification in the insert in E. This is also observed in sciatic nerve endoneurial microvessels in transgenic GDNF wildtype mice following non-transecting crush injury followed by SRC kinase inhibition to impede BNB functional recovery (G). A normal sciatic nerve endoneurial microvessel from the contralateral uninjured side of the same transgenic GDNF wildtype mouse is shown for structural comparison (H).