Table 2.

Summary of ratios between fed and fasted states for log- transformed PK parameters of salicylic acid

PK parameter	N	LSM		Geometric mean		Ratioa (%)	90% CIb	ANOVA p-valuec
		Fed	Fasted	Fed	Fasted
AUC0−t (ng × min/mL)	20	9.53	9.65	13,772.6	15,521.3	88.7	(82.27, 95.8)	0.01
AUC0−∞ (ng × min/mL)	20	9.55	9.66	14,000.7	15,767.0	88.8	(82.2, 96.0)	0.02
Cmax (ng/mL)	20	3.36	3.61	28.9	37.1	77.8	(72.3, 83.6)	< 0.0001

ANOVA analysis of variance; AUC_0−t area-under-the-curve; AUC_0−∞ AUC_0−t extrapolated to infinity; C_max maximum plasma concentration; CI confidence interval; LSM least square mean; mL milliliters; min minutes; N number of subjects; ng nanograms; PK pharmacokinetic; SD standard deviation

^aRatio = 100% × geometric mean (fed) / geometric mean (fasted)

^b90% Confidence interval on the ratio of fed and fasted

^cp-value for the difference in the treatment estimates. Significant difference was defined as p-value < 0.05