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. 2020 Apr 9;10:6147. doi: 10.1038/s41598-020-63169-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PD2a1/b1 neurons contribute to aversive responses to high odor concentrations. (a) An example of traces obtained for naïve flies for 2-butanone. Gray, parental control groups; red, the experimental group at 32 °C; blue, the experimental control group at 23 °C. Naïve response to an odor (gray) was tested against mineral oil (white). (b) Mean valence scores (see Methods) from experiments as in a, for the designated odors. Odors are arranged according to their response profile as in Fig. 2 and Supplementary Fig. S2. A consistent shift towards more positive valence values was observed during PD2a1/b1 inhibition for all odors that activate PD2a1/b1 neurons, except for ethyl lactate. No effect during PD2a1/b1 inhibition was observed for odors that only weakly activate PD2a1/b1 neurons. (137 ≥ n ≥ 21 flies for all conditions, * indicates a significant difference of the indicated group from all other groups according to a multiple comparison test. The lowest value of all multiple comparison tests is presented. # indicates a significant difference only between the two indicated groups. *, ^#p < 0.05, **, ^##p < 0.01, ^###p < 0.0005, ****p < 0.0001, see Supplementary Table S1 for statistical analysis).