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. 2020 Apr 9;10:6124. doi: 10.1038/s41598-020-62823-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The mRNA expression level of SMPD1 was investigated for several CRC cohorts. The n number of independent patient samples is indicated in each panel. An unpaired t-test was performed to examine the difference between the expression levels of SMPD1 mRNA in normal and CRC tissues. Error bars indicate standard deviations. (B) FOLFOX is 5-FU+ l-LV+L-OHP and is a standard chemotherapy regimen for CRC. SMPD1 mRNA expression level in FOLFOX responder and non-responder group from Tsuji’s cohort.