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. 2020 Apr 9;10:6115. doi: 10.1038/s41598-020-63150-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MAOA is down-regulated in NPC. (A) Two microarray datasets (GSE12452 and GSE34573) showed that MAOA mRNA was significantly down-regulated in micro-dissected NPC cells compared with normal epithelium (p < 0.01). (B) Compared to NP460hTert, MAOA mRNA and protein levels were decreased in seven (C666-1, CNE1, CNE2, HONE1, SUNE1, TW01 and TW04) out of eight NPC cell lines examined. Densitometric data are expressed as the relative density (normalized to β-actin). Full-length blots are presented in Supplementary Fig. S1. ***p < 0.001. (C) Immunohistochemical analysis of MAOA expression in primary NPC. (a,b): A case demonstrating positive MAOA staining. The adjacent normal epithelium (asterisk) and underlying islands of carcinoma (arrow) are both strongly positive; (c) High-power view of area highlighted by arrow in b. (d,e): A case demonstrating moderately positive MAOA staining of carcinoma (arrow) beneath the overlying epithelium (asterisk) that is strongly positive; (f) High-power view of area highlighted by arrow in e. (g,h): A case demonstrating negative MAOA staining. The adjacent normal epithelium (asterisk) is strongly positive whilst there is no staining in the carcinoma (arrow); (i) High-power view of area highlighted by arrow in h. Original magnification (a,d,g) ×40; (b,e,h) ×100; (c,f,i) ×400.