Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 9;10:6115. doi: 10.1038/s41598-020-63150-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

IL-6/IL-6R suppresses MAOA expression through STAT3. (A) Increased expression of IL-6R in NP460hTert and HONE1 cells following EBV infection. (B) Both the mRNA and protein levels of MAOA were decreased in NP460hTert/EBV following addition of IL-6 (50 ng/ml) and these effects were rescued by blocking IL-6R using an anti-IL-6R neutralizing antibody (1 µg/ml). (C) Following the addition of IL-6 in NP460hTert/EBV, the decrease in MAOA levels was accompanied by the activation of STAT3 and the expression of MAOA was restored with concomitant inhibition of phosphorylated STAT3 following the treatment with an IL-6R neutralising antibody. (D) Treatment of NP460hTert with a STAT3 inhibitor, Stattic, restored the expression of MAOA. Densitometric data are expressed as the relative density (MAOA: normalized to β-actin; pSTAT3: normalized to total STAT3). Full-length blots are presented in Supplementary Fig. S1. ***p < 0.001.