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. 2020 Apr 9;10:6109. doi: 10.1038/s41598-020-62894-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Barcoded particles revealed different ΔE responses for microsphere arrays of different arrangements. (i) Mesh view of the microfluidic channel with the barcoded particle and an array of microspheres (MS); in (a) rows of two across, (c) with a diagonal array of two MS, and (e) in columns of two MS attached to the bottom of the barcoded particle. (ii) Transverse view of the barcoded particle with an array of MS; in (a) rows of two between each barcoded region, (c) in columns of two MS, and (e) with a diagonal array of two MS. COMSOL modeling of the differential bipolar electrical signature, ΔE, measured for the barcoded particle with no adsorbed MS (blue), (b) MS arrays two across (orange), (d) with diagonal arrays of two MS (green), and (f) MS arrays of two in columns (green). Here, a 10 µm MS was modeled, and the different orientations of MS assembled on the barcoded particle can be visualized through unique electrical responses.