TABLE 4.
Assessment of T. rubrum and T. mentagrophytes growth inhibition by drug-containing water-soluble films using disc diffusion assay.
Test organism |
Inhibition zone diameters in (mm)* |
|||||||
U 10% | U 20% | U 40% | M | M + U 10% | M + U 20% | M + U 40% | Placebo film | |
T. rubrum (ATCC 28188) | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 21 ± 0.06 | 44 ± 0.03 | 44 ± 0.05 | 0 ± 0 |
mentagrophytes (ATCC 24953) | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 33 ± 0.11 | 40 ± 0.07 | 40 ± 0.1 | 0 ± 0 |
*U, urea; M, miconazole (0.004 mg/L); each experiment was carried out in triplicates and the average was calculated ± standard deviation (SD). M, miconazole MFC.