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. 2020 Apr 3;11:542. doi: 10.3389/fimmu.2020.00542

Figure 4.

Figure 4

Delivery of IFNα9 into the tumor microenvironment by gB-specific CD8+ T cells improves survival. (A) gBT.I cell activation and transduction began 2 days prior to subcutaneous tumor challenge of WT mice with 5 × 105 B16_gB cells. Four days post-tumor inoculation, mice were subjected to 500 rads total body irradiation before receiving 3 × 106 gBT.I cells (gBT.I-GFP) or gBT.I cells lacking the IFNAR (gBT.I_IFNARo/o-GFP) not secreting IFNα, or secreting IFNα4 or IFNα9. (B) Survival was monitored over time and data pooled from two independent repeats (n = 5–10 mice per group). The IFNα9 cohort was compared to GFP alone and IFNα4 cohorts using the Log-Rank Mantel-Cox test, **p < 0.01 for both comparisons.