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. 2020 Apr 3;11:376. doi: 10.3389/fphar.2020.00376

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Copyright © 2020 He, Guo, Zhao, Xu, Wang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FA ameliorated lipopolysaccharide-induced barrier dysfunction via miR-200c-3p-mediated activation of PI3K/AKT pathway in Caco-2 cells. FA exhibited the protective effects on LPS-induced barrier dysfunction involving in miR-200c-3p and PTEN/PI3K/Akt signaling pathway. FA promotes activation of PI3K/AKT pathway by miR-200c-3p-mediated suppression of the negative mediator PTEN, which, in turn, maintains TJ function and thus ameliorates LPS-induced intestinal epithelial barrier dysfunction.