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The roles of ncRNAs in CD4+ T cell dysfunction and pathogenesis of SLE. The aberrant expression of ncRNAs disturbs the normal biological processes of CD4+ T cells, and then leads to the phenotypic and functional changes of CD4+ T cells, including the imbalance of Th1/Th2, increased proportions of pro-inflammatory Th17 cells and Tfh cells, as well as deficient frequency and function of Treg cells, which contribute to the occurrence and development of SLE.
