Table 6.
ncRNAs involved in Treg cells.
| ncRNA | Target gene | Biological function | Reference |
|---|---|---|---|
| miR-155 | SOSC1 | Promotes the expression of IL-2R by down-regulating SOSC1 | (87) |
| miR-142-3p | AC9 | Limits the function of Treg cells by reducing the levelof intracellular cAMP | (88) |
| miR-142-5p | Pde3b | Decreases the concentration of intracellular cAMP and leads to Treg cell dysfunction | (89) |
| miR-31 | Foxp3, Gprc5a, and Ppp6C | Inhibits Treg cell differentiation | (84, 85) |
| miR-125a | Stat3, Ifng, and Il13 |
Facilitates the differentiation and immune regulatory role of Treg cells | (86) |
| miR-99a and miR-150 | Mtor | Promotes Treg cell differentiation at the expense of inhibiting Th17 cells | (90) |
| Lnc-Flatr | Foxp3 | Promotes Treg cell development by enhancing Foxp3 | (91) |
| Lnc-smad3 | Smad3 | Inhibits the expression of Foxp3 by suppressing smad3 | (92) |
| Lnc-Flicr | Foxp3 | Influences the chromatin accessibility of Foxp3 | (93) |