Table 8.
The roles of ncRNAs in the aberrant differentiation of CD4+ T cells in SLE.
| ncRNA | Regulated CD4+ T cell subset | Molecular mechanism | Reference |
|---|---|---|---|
| miR-155 | Treg cells | Targets CD62L to alter the phenotype of Treg cells |
(107) |
| miR-155 | Th1, Th2, and Th17 cells |
Targets S1PR1 to regulate the production of IFN-γ, IL-4, and IL-17A |
(108) |
| miR-21 | Th17/Treg balance | Inhibits CD40:CD40L and CD28:CD80/86 signaling pathways to destroy T cell tolerance | (114) |
| miR-31 | Treg cells | Plays a role in IL-2 deficiency | (116) |
| miR-183C | Th17/Treg balance | Targets mTOR signaling to regulate Th17/Treg cell balance |
(120) |
| miR-17-92 | Tfh cells | Regulates transcriptional factor BCL6 or Pten and Bim | (68, 124) |
| miR-873 | Th17 cell | Targets Foxp1 to promote the differentiation of Th17 cells and the production of IL-17A |
(125) |
| miR-34a | Th17/Treg balance | Inhibits Treg cell differentiation by suppressing Foxp3 and promotes Th17 cell differentiation by down-regulating RORγt | (126) |
| miR-326 | Treg cells | Targets Est1 to regulate Treg cell differentiation | (127) |
| LncRNA-NEAT1 | Th1 and Tfh cells |
Regulates Th1 cell related-chemotactic factor receptor CXCL10, CCL8, and Tfh cell-related cytokine IL-6 | (128) |