Table 3.
Univariate and multivariate analysis of factors affecting survival after brain metastasis (SABM).
| Features | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | |
| Age | ||||
| <40 | 1 (Reference) | |||
| 40–59 | 0.86 (0.51–1.45) | 0.578 | ||
| ≥60 | 1.29 (0.54–3.04) | 0.568 | ||
| TNM stage | ||||
| I | 1 (Reference) | |||
| II | 2.01 (0.27–15.1) | 0.500 | ||
| III | 4.31 (0.59–31.7) | 0.151 | ||
| IV | 4.34 (0.58–32.5) | 0.153 | ||
| Molecular subtypes | ||||
| Luminal (HER2-) | 1 (Reference) | 1 (Reference) | ||
| HER2+ | 0.92 (0.53–1.60) | 0.756 | 0.89 (0.50–1.56) | 0.671 |
| Triple negative | 2.04 (1.14–3.66) | 0.017 | 2.02 (1.12–3.64) | 0.012 |
| Pathology type | ||||
| Ductal | 1 (Reference) | |||
| lobular | 1.21 (0.38–3.87) | 0.151 | ||
| other | 1.61 (0.81–3.67) | 0.422 | ||
| Histological grade | ||||
| II | 1 (Reference) | |||
| III | 1.70 (0.74–3.91) | 0.209 | ||
| Bone metastasis | ||||
| No | 1 (Reference) | |||
| Yes | 0.65 (0.40–1.06) | 0.081 | ||
| Liver metastais | ||||
| No | 1 (Reference) | 1 (Reference) | ||
| Yes | 1.65 (1.04–2.63) | 0.035 | 1.34 (0.83–2.16) | 0.228 |
| Lung metastasis | ||||
| No | 1 (Reference) | |||
| Yes | 0.94 (0.59–1.50) | 0.800 | ||
| Number of brain metastasis | ||||
| Single | 1 (Reference) | |||
| Multiple | 1.66 (0.97–2.85) | 0.066 | ||
| Surgical resection of brain tumor | ||||
| No | 1 (Reference) | 1 (Reference) | ||
| Yes | 0.17 (0.04–0.70) | 0.014 | 0.31 (0.15–0.65) | 0.002 |
| Whole brain radiotherapy | ||||
| No | 1 (Reference) | 1 (Reference) | ||
| Yes | 0.55 (0.5–0.89) | 0.013 | 0.57 (0.35–0.93) | 0.023 |
| Stereotactic surgery | ||||
| No | 1 (Reference) | |||
| Yes | 0.68 (0.40–1.14) | 0.143 | ||