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. 2020 Apr 3;11:548. doi: 10.3389/fimmu.2020.00548

Table 2.

Timeline of the disease diagnostics and treatment.

Days Diagnostics Treatment Aim
Ceasarean section Basic blood count,
C-reactive protein, blood chemical values,
hemolysis markers, coagulation factors and descriptive, antiphospholipid antibodies, Coombs test, plasma ADAMTS13 activity, and antinuclear antibodies
Transfer to ICU To exclude TTP, antiphospholipid syndrome, SLE, and autoimmune hemolytic anemia
Postpartum day 1 Plasma C3 and C4 levels, Complement terminal complex-level, C4A and C4B genetic testing Plasma exchange
Postpartum day 2 Hepatitis B and C, HIV,
and aHUS genetic tests (Complement system)
Plasma exchange,
Hemodialysis
To exclude viral hepatitis as a cause of liver damage
Postpartum day 3 Stool sample testing the pathogens causing typical HUS Transfer back to Women's Hospital recovery room were observation and symptomatic therapy continued To exclude typical HUS
Postpartum day 4 Basic laboratory tests concerning hemolysis, liver and kidney function, platelets, and coagulation Hemodialysis,
Transfer to the department of Nephrology,
first dose of Eculizumab
Diagnosis of aHUS was placed
Postpartum day 5 Basic laboratory tests concerning hemolysis, liver and kidney function, platelets, and coagulation
Postpartum day 6 Basic laboratory tests concerning hemolysis, liver and kidney function, platelets, and coagulation Hemodialysis