Table 4.
Unadjusted and Final Model Risk Differences for Failure by Exploratory Day 2 Area Under the Curve (AUC) and AUC/Minimum Inhibitory Concentration Predictors
| Integrated Exposure (PK/PD) Measure | Exposure Category | No. of Patients | Proportion, % | Unadjusted | Adjusted | ||
|---|---|---|---|---|---|---|---|
| Point Estimate | (95% CI) | Point Estimate | (95% CI) | ||||
| CART AUC/MICBMD cutpoint | ≤345.88 | 30 | 3.33 | 0.17 | (.09–.25) | 0.17 | (–.13 to .48) |
| >345.88 | 235 | 20.43 | |||||
| RR AUC/MICBMD cutpoint | <500 | 85 | 11.76 | 0.10 | (.01–.19) | 0.03 | (–.06 to .11) |
| ≥500 | 180 | 21.67 | |||||
| CART AUC/MICEtest cutpoint | <344.9 | 81 | 9.88 | 0.12 | (.04–.21) | 0.10 | (–.04 to .24) |
| ≥344.9 | 184 | 22.28 | |||||
| RR AUC/MICEtest cutpoint | <350 | 83 | 10.84 | 0.11 | (.02–.20) | 0.08 | (–.06 to .22) |
| ≥350 | 182 | 21.98 |
Abbreviations: AUC, area under the curve; CART, classification and regression tree; CI, confidence interval; MICBMD, minimum inhibitory concentration by broth microdilution; MICEtest, minimum inhibitory concentration by Etest; PK/PD, pharmacokinetic/pharmacodynamic; RR, relative risk.