Table 5.
Acute Kidney Injury by Exploratory Day 2 Area Under the Curve Exposures
| Categorical Outcome | Integrated Exposure (PK/PD) Measure | Exposure Category | No. of Patients | Proportion, % | Cut-point Level Comparison | Unadjusted | Adjusted | ||
|---|---|---|---|---|---|---|---|---|---|
| Point Estimate | (95% CI) | Point Estimate | (95% CI) | ||||||
| AKI | CART AUC cutpoint | ≤343 | 30 | 10 | High vs low | 0.29 | (.08–.49) | 0.26 | (.00–.51) |
| >343 to 793 | 151 | 26.49 | High vs medium | 0.12 | (–.06 to .31) | 0.12 | (–.07 to .32) | ||
| ≥793 | 31 | 38.71 | Medium vs low | 0.16 | (.04–.29) | 0.14 | (–.06 to .33) | ||
| RR AUC cutpoint | <550 | 104 | 21.15 | … | 0.09 | (–.02 to .21) | 0.12 | (–.01 to .24) | |
| ≥550 | 108 | 30.56 | … | ||||||
| VINT | CART AUC cutpoint | ≤343 | 30 | 10 | High vs low | 0.32 | (.12–.52) | 0.27 | (.01–.54) |
| >343 to 793 | 151 | 29.14 | High vs medium | 0.13 | (–.06 to .32) | 0.13 | (–.07 to .32) | ||
| ≥793 | 31 | 41.94 | Medium vs low | 0.19 | (.06–.32) | 0.15 | (–.06 to .35) | ||
| RR AUC cutpoint | <550 | 104 | 23.08 | … | 0.10 | (–.02 to .22) | 0.12 | (.00–.25) | |
| ≥550 | 108 | 33.33 | … |
Abbreviations: AKI, acute kidney injury; AUC, area under the curve; CART, classification and regression tree; CI, confidence interval; PK/PD, pharmacokinetic/pharmacodynamic; RR, relative risk; VINT; vancomycin-induced nephrotoxicity.