Table 2.
Prevalence of Histologic Anal High-grade Squamous Intraepithelial Lesions According to Baseline Cervical and Anal Cytology and Cervical Human Papillomavirus Results
| Characteristic | Participants With Anal HSIL/Total Participants, No. | Prevalence of Anal HSIL, % (95% CI) | P Valuea |
|---|---|---|---|
| Cervical cytology (n = 251) | .021 | ||
| Negative | 44/176 | 25.0 (18.8–32.1) | |
| ASC-US/LSIL | 18/64 | 28.1 (17.6–40.8) | |
| ASC-H/HSIL | 7/11 | 63.6 (30.8–89.1) | |
| Unevaluable (n = 3) | … | … | |
| Missing (n = 2) | … | … | |
| Cervix HPV HC2 (n = 251) | .019 | ||
| HPV positive | 26/72 | 36.1 (25.1–48.3) | |
| HPV negative | 39/179 | 21.8 (16.0–28.6) | |
| Missing (n = 5) | … | … | |
| Anal cytology (n = 248) | < .001 | ||
| Negative | 12/98 | 12.2 (6.5–20.4) | |
| ASC-US/LSIL | 37/128 | 28.9 (21.2–37.6) | |
| ASC-H/HSIL | 17/22 | 77.3 (54.6–92.2) | |
| Unevaluable (n = 8) | … | … |
Abbreviations: ASC-H, atypical squamous cells, high-grade squamous intraepithelial lesion cannot be excluded; ASC-US, atypical squamous cells of undetermined significance; CI, confidence interval; HC2, Hybrid Capture 2 test; HPV, human papillomavirus; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion.
aχ2 test.