Table 2.
Incremental Cost-effectiveness Ratios (Incremental Cost per Life-year Saved) Comparing the Intervention With Standard Care According to Baseline CD4 Cell Count
| Standard Care Arm | Intervention Arm | Incremental Comparison of the Intervention vs Standard Care | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All-cause Mortality | All-cause Mortality | |||||||||||
| CD4 Cell Count | Life Expectancy, ya (95% CI) | No. | Mean Total Cost/Person, US$ (95% CI) | Events (95% CI) | Death Rate (95% CI) | No. | Mean Total Cost/Person, US$ (95% CI) | Events (95% CI) | Death Rate (95% CI) | Incremental Cost/Personb, US$ (95% CI) | Incremental Deathb, % (95% CI) | ICERc (95% CI) |
| <200 cells/μL | 24.0 | 998 | 262 | 180 | 18.0 | 1001 | 339 | 134 | 13.4 | 77 | –4.6 | 70 |
| (22.2–25.8) | (254–269) | (156–203) | (15.6–20.3) | (331–347) | (113–156) | (11.3–15.6) | (66–88) | (–7.8 to –1.3) | (43–211) | |||
| <100 cells/μL | 18.7 | 707 | 262 | 144 | 20.2 | 724 | 341 | 114 | 15.7 | 79 | –4.5 | 91 |
| (17.2–20.3) | (253–271) | (123–165) | (17.4–23.3) | (331–350) | (94–134) | (13.0–18.5) | (65–92) | (–8.6 to –.6) | (49–443) | |||
Abbreviations: CI, confidence interval; ICER, incremental cost-effectiveness ratio.
aWeighted life expectancy based on a previous study [15].
bDifferences were estimated using regression equations adjusting for body weight and hemoglobin levels measured at baseline.
cEstimated by dividing incremental cost by the mean number of life-years saved (ie, incremental death multiplied by life expectancy).