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. 2020 Mar 24;15:1983–1996. doi: 10.2147/IJN.S237182

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© 2020 Shu et al.

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Therapeutic immunization with FGF-2 protein- or peptide 12-conjugated VLPs suppresses the growth of established tumors. Effective IgG antibody responses were induced after the tumor size reached a diameter of 5–6 mm, and the carrier or PBS was used instead of FGF-2 protein- or peptide 12-conjugated VLPs as the controls. (A) The protocol applied in the mouse model; (B) the FGF-2-specific IgG responses from the third immunization; (C) tumor growth was dynamically monitored once a week (***p < 0.001; n = 5/group).