Table 2. Clinical interventions using inactive genome editors as transcription factors.

Vector	Transcription factor type	Phase	Target Gene and effect	Disease	Ex vivo/in vivo	Intervention	Sponsor organization	Country	NCT number	Date posted
Naked plasmid	ZFP TF	I	VEGF-A increased expression	Artheriosclerosis and intermittent claudication (lower limb ischemia)	In vivo	Injection into the leg	National Heart, Lung, and Blood Institute (NHLBI)	U.S.A.	NCT00080392	3/30/2004
	ZFP TF	I	VEGF increased expression	Diabetic limb neuropathy	In vivo	Injection into the leg	Sangamo Therapeutics	U.S.A.	NCT00110500	5/10/2005
	ZFP TF	II	VEGF increased expression	Diabetes type 1 and 2, diabetic limb neuropathy	In vivo	Injection into the leg	Sangamo Therapeutics	U.S.A.	NCT00406458	12/4/2006
	ZFP TF	II	VEGF increased expression	Diabetes type 1 and 2, diabetic limb neuropathy	In vivo	Injection into the leg	Sangamo Therapeutics	U.S.A.	NCT00476931	5/22/2007
	ZFP TF	II	VEGF increased expression	Diabetes type 1 and 2, diabetic limb neuropathy	In vivo	Injection into the leg	Sangamo Therapeutics	U.S.A.	NCT00665145	4/23/2008
	ZFP TF	II	VEGF increased expression	Amyotrophic lateral sclerosis	In vivo	Injection into neck, arm, or leg	Sangamo Therapeutics	U.S.A.	NCT00748501	9/8/2008
	ZFP TF	II	VEGF increased expression	Diabetes type 1 and 2, diabetic limb neuropathy	In vivo	Injection into the leg	Sangamo Therapeutics	U.S.A.	NCT01079325	3/3/2010

U.S. clinical trials data base (clinicaltrials.gov) was accessed on 1/1/2020.