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. 2020 Apr 3;8:216. doi: 10.3389/fcell.2020.00216

FIGURE 2.

FIGURE 2

Effect of cocaine (COC), SCH23390 (SCH), and SCH 15 min before COC (SCH-COC) treatments on H3 and H4 post-traslational modifications expression in male germ cells. Protein expression levels (western blot) of (A) H3K9me3, ANOVA-Bonferroni F(3,20) = 6.87, p = 0.004. (B) H3K27me3, Kruskal–Wallis-paired comparisons H = 7.93, p = 0.047. (C) H3K27ac, ANOVA-Bonferroni F(3,20) = 8.86, p = 0.0009. (D) H3K4me3, ANOVA-Bonferroni F(3,23) = 23.84, p < 0.0001. (E) H3K9ac, Kruskal–Wallis-paired comparisons H = 13.5, p = 0.004. (F) H4K16ac, Kruskal–Wallis-paired comparisons H = 12.6, p = 0.005. Values indicate mean ± SEM (n = 5–7). *p < 0.05 different from VEH, $p < 0.05 different from COC.