FIGURE 6.

Exposure to gossypol induced progenitor apoptotic cell death. (A) Representative Western blots of caspase-3, NF-κB, ERK, p-ERK, p38, p-p38 and β-actin are shown and densitometry was used to quantify the protein levels in the developmental cerebral cortex. (B,C) Relative protein levels of caspase-3 and NF-κB, the expressions of caspase-3 and NF-κB were increased after the treatment of gossypol. (D,E) Ratio of phosphorylation of ERK and ERK, and ratio of phosphorylation of p38 and p38. Exposure to gossypol decreased the phosphorylation of ERK and p38. Results are presented as the mean ± SEM (n = 5 per group). *p < 0.05 and **p < 0.01 compared with the control group. p-ERK: phospho-ERK; p-p38: phospho-p38.