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. 2020 Apr 3;10:435. doi: 10.3389/fonc.2020.00435

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Copyright © 2020 Panina, Pei, Baran, Konopleva and Kirienko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synergy landscapes for mitocan-based AML drug combinations. Drug combination landscapes were built using Bioconductor package “synergyfinder.” One representative replicate (with maximal synergy closest to its average value) is shown. (A) Examples of drug combinations (n = 29/36), synergistic against AML cell lines. Shown are drug combinations having highest (>70) cumulative synergy against MOLM-13 (top) and OCI-AML2 (bottom) cells. (B) Example of drug combination with opposite profiles in MOLM-13 and OCI-AML2 (n = 5/36). (C) Examples of antagonistic drug combinations for MOLM-13 (left) and OCI-AML2 (right) cells (n = 2/36). Drug combination landscapes: z-axis, synergy score (ranges from −40, green, to +40, red); x/y-axes, drug1/drug2 concentration range, respectively. For specific drug names and drug concentrations, refer to Table S4.