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. 2020 Apr 3;10:435. doi: 10.3389/fonc.2020.00435

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Copyright © 2020 Panina, Pei, Baran, Konopleva and Kirienko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drug combinations demonstrate higher synergy in AML than in healthy cells. Synergy landscapes for MOLM-13, OCI-AML2, or healthy PBMCs after treatment with (A) IACS-010759/vinorelbine, (B) rotenone/2-deoxy-D-glucose, (C) CCCP/dasatinib, and (D) ABT-199/lonidamine. Drug combination landscapes: z-axis, synergy score (ranges from −40 in green to +40 in red); x/y-axes, drug1/drug2 concentration range, respectively. Drug combination landscapes were built using Bioconductor package “synergyfinder.” One representative replicate (with maximal synergy closest to the average value of three biological replicates) is shown.