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. 2020 Feb 26;12(3):610. doi: 10.3390/nu12030610

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of 5-uRCK or ellagic acid (EA) on the expression of HMGCR and SREBP-2 in the livers of rats fed an HCD. Relative mRNA expression of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) (A) and SREBP-2 (B) was analyzed after 5-uRCK or ellagic acid treatment for five weeks. The gene expression levels were quantified by qPCR. Experiment was repeated independently three times (n = 6–8 rats per group each time) and the RT-PCR product is representative of one of them. Each bar graph represents the mean ± SD of 6–8 rats per group (n = 6–8 rats/group, 3 times repeat). P values for comparisons with control groups (NCD groups) are denoted as * p < 0.05 and *** p < 0.001, and those for comparisons with HCD groups are denoted as ^# p < 0.05, ^## p < 0.01, and ^### p < 0.001.