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. 2020 Feb 26;12(3):610. doi: 10.3390/nu12030610

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of 5-uRCK or ellagic acid (EA) on the phosphorylation of AMPK and the expression of cholesterol biosynthesis-related proteins in the livers of rats fed an HCD. (A) The protein expression levels of p-AMPK, AMPK, p-HMGCR, HMGCR, precursor SREBP-2 (pSREBP-2), mature SREBP-2 (mSREBP-2), and INSIG-1 in liver tissues were measured by Western blotting. (B) The bar graphs indicate the average p-AMPK and AMPK levels. (C) The bar graphs indicate the average p-HMGCR and HMGCR levels. (D) The bar graph indicates the average pSREBP-2 and mSREBP-2 levels. (E) The bar graph indicates the average INSIG-1 levels. The data are expressed as the mean ± SD. P values for comparisons with control groups (NCD groups) are denoted as * p < 0.05, ** p < 0.01 and *** p < 0.001, and those for comparisons with HCD groups are denoted as ^# p < 0.05, ^## p < 0.01, and ^### p < 0.001.