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Rats were treated with 1% CMC, SIL, MSB, APAP, APAP + SIL, APAP + MSB or APAP + SIL + MSB. Periorbital blood was collected on Day 13, and the serum was tested for TNF-α (A) and IL-1β (B) levels. * Significant difference (p < 0.05) between groups; data were analyzed using one-way ANOVA. Abbreviations: APAP, N-acetyl-p-aminophenol or paracetamol (acetaminophen); CMC, carboxymethylcellulose; IL-1β, interleukin 1β; MSB, MegaSporeBiotic™; SIL, silymarin; TNF-α, tumoral necrosis factor α.
