Table 3.
Hazard ratio (95% CI) of overall breast cancer—probable cases—and by menopausal status according to binge drinking habit.
| Probable Breast Cancer Cases | No Binge Drinking | Binge Drinking |
|---|---|---|
| Overall | ||
| Cases/women-years | 135/80,452 | 32/24,479 |
| Age adjusted | 1 (Ref.) | 1.29 (0.87–1.94) |
| Multivar. adjusted * | 1 (Ref.) | 1.22 (0.81–1.85) |
| Premenopausal | ||
| Cases/women-years | 72/61,155 | 26/22,796 |
| Age adjusted | 1 (Ref.) | 1.45 (0.92–2.30) |
| Multivar. adjusted * | 1 (Ref.) | 1.28 (0.79–2.06) |
| Postmenopausal | ||
| Cases/women-years | 52/16,405 | 5/1377 |
| Age adjusted | 1 (Ref.) | 1.10 (0.44–2.79) |
| Multivar. adjusted * | 1 (Ref.) | 1.27 (0.49–3.30) |
* Adjusted for height (cm), family history of breast cancer (no history, before 45 years, after 45 years), smoking habit (never, former or current smoker), lifetime tobacco exposure (pack-years), age at menarche (<10 years, 10–16 years or >16 years), obstetric history (5 categories), lifetime breast-feeding (months), years of university studies (years), Mediterranean Diet Score (0–8), alcohol consumption (g/d), total daily energy intake (tertiles of kcal/d), body-mass index (kg/m2), consumption of sugar-sweetened beverages (servings/day) and TV-watching (h/d). Only for postmenopausal women: hormone replacement therapy (yes/no), duration of hormone replacement therapy (months) and age at menopause (<50 years, 50–55 years or >55 years). Age as underlying time variable. Stratified analyses by recruitment period and age (decades).