Table 2.
Unadjusted and adjusted hazard ratio † (95% CI) of asthma among Danish children age 3–9 years, according to quintiles of neonatal 25(OH)D3 concentrations.
| Unadjusted (n = 2334) | Adjusted ‡ (n = 2334) | Adjusted § (n = 1984) | |
|---|---|---|---|
| Quintiles limit, nmol/L | |||
| Q1 (0.0–11.6) | 1 (ref) | 1 (ref) | 1 (ref) |
| Q2 (11.6–20.0) | 0.93 (0.72, 1.20) | 0.97 (0.74, 1.28) | 0.90 (0.66, 1.23) |
| Q3 (20.0–29.3) | 1.00 (0.78, 1.28) | 0.96 (0.72, 1.28) | 0.94 (0.68, 1.30) |
| Q4 (29.3–43.9) | 0.97 (0.75, 1.25) | 0.91 (0.67, 1.23) | 0.82 (0.58, 1.14) |
| Q5 (43.9–110.8) | 0.61 (0.46, 0.80) | 0.55 (0.39, 0.77) | 0.51 (0.35, 0.75) |
| Wald test | 0.002 | 0.001 | 0.003 |
† Weighted Cox regression analysis. ‡ Adjusted for sex, month of birth, birthweight, preterm birth, caesarean section, parity, maternal age, maternal ethnicity, maternal education, maternal asthma, and paternal asthma. § Adjusted for covariates in model ‡ and in addition adjusted for maternal smoking.