Table 2.
Relative abundance of microbiota (genus level) throughout administration of 5% BTS in ob/ob mice.
| Phylum | Genus | CONT Group (%) Mean ± SD |
BTS Group (%) Mean ± SD |
Ratio | p-Value |
|---|---|---|---|---|---|
| Verrucomicrobia | Akkermansia | 0.03 ± 0.07 | 3.14 ± 2.25 | 93.36 | 1.60 × 10−6 |
| Bacteroidetes | Bacteroides | 0.91 ± 0.85 | 9.58 ± 6.90 | 10.50 | 1.69 × 10−11 |
| Prevotella | 5.24 ± 3.14 | 1.60 ± 0.97 | 0.30 | 3.32 × 10−9 | |
| Parabacteroides | 5.58 ± 5.79 | 15.53 ± 6.61 | 2.78 | 3.83 × 10−8 | |
| [Prevotella] | BLD | 0.78 ± 1.13 | 777.97 | 2.31 × 10−4 | |
| unknown genus in order Bacteroidales | BLD | 0.01 ± 0.01 | 5.94 | 2.07 × 10−2 | |
| Firmicutes | unknown genus in family Erysipelotrichaceae | 0.14 ± 0.13 | 0.84 ± 0.55 | 6.00 | 1.77 × 10−9 |
| unknown genus in order Clostridiales | 43.33 ± 11.29 | 23.36 ± 15.45 | 0.54 | 2.87 × 10−6 | |
| [Eubacterium] | <0.01 | 0.11 ± 0.14 | 167.26 | 1.35 × 10−5 | |
| Anaerotruncus | BLD | 0.01 ± 0.01 | 9.82 | 5.19 × 10−4 | |
| unknown genus in family Christensenellaceae | 0.01 ± 0.01 | 0.02 ± 0.03 | 4.07 | 1.06 × 10−2 | |
| Clostridium | 0.01 ± 0.01 | <0.01 | 0.39 | 1.41 × 10−2 | |
| unknown genus in family Lachnospiraceae | 0.14 ± 0.28 | 0.05 ± 0.08 | 0.37 | 2.38 × 10−2 | |
| Streptococcus | <0.01 | 0.01 ± 0.01 | 6.29 | 2.44 × 10−2 | |
| Coprobacillus | <0.01 | 0.03 ± 0.04 | 6.40 | 3.58 × 10−2 | |
| Sporosarcina | 0.01 ± 0.03 | BLD | 0.12 | 4.10 × 10−2 | |
| Ruminococcus | 0.98 ± 0.70 | 0.65 ± 0.52 | 0.66 | 4.28 × 10−2 | |
| Proteobacteria | unknown genus in family Enterobacteriaceae | 0.06 ± 0.27 | 2.39 ± 3.55 | 37.59 | 2.03 × 10−8 |
| unknown genus in family Helicobacteraceae | 1.24 ± 2.22 | <0.01 | <0.01 | 8.06 × 10−3 | |
| Tenericutes | unknown order in RF39 | 0.23 ± 0.26 | 0.07 ± 0.05 | 0.30 | 2.52 × 10−4 |
| Actinobacteria | Bifidobacterium | BLD | 0.03 ± 0.06 | 30.56 | 2.42 × 10−3 |
Relative abundance of microbes throughout administration with 5% (w/w) BTS determined at the genus level. Statistical differences between CONT and BTS groups were examined by the Mann–Whitney rank sum test, showing genus with significant alteration in p-value < 0.05. When genus could not be detected, abundance value was provisionally assigned as 0.001%. Ratio was calculated as BTS group/CONT group. CONT, ob/ob mice fed a standard diet. BTS, ob/ob mice fed a standard diet with 5% BTS. BLD, below limit of detection in all samples; bold, relative abundance >1%; underlined bold, ratio was >10 or <0.1 and the relative abundance >1%.