Figure 6.

Interaction of dietary VB2, the gut microbiota, and glycolate accumulation in gut microbiota and the mouse host. (A) Control diet feeding with normal gut microbiota sustains a sufficient VB2 supply from both sources and preserves VB2 sufficiency. (B) VB2- diet feeding with normal gut microbiota sustains a VB2 supply from the gut microbiota only in the short term and before VB2 deficiency gradually develops. (C) Feeding of a VB2- diet in the presence of disrupted gut microbiota due to antibiotic treatment does not sustain adequate VB2 supplies and rapidly induces VB2 deficiency. (D) Time course of total VB2 supply (left) and VB2 deficiency (right) in mice fed the VB2- diet with or without antibiotic treatment.