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. 2020 Mar 13;12(3):762. doi: 10.3390/nu12030762

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Regulation of intestinal zinc absorption. Potential regulatory mechanisms of zinc absorption into enterocytes during (A) zinc excess, (B) adequate supply, and (C) zinc deficiency, based on experimental data on the zinc-dependent expression pattern of the intestinal zinc transporters (ZnT) and the Zrt-, Irt-like protein (ZIP)-transporters as well as metallothioneins (MT). Enterocyte zinc homeostasis is controlled by these proteins, regulating the amount of intestinally absorbed and basolaterally exported zinc [150]. The subcellular localization of ZnT-5, ZnT-6, and ZnT-7 in enterocytes is not yet fully investigated. Zinc-dependent up-regulation or downregulation of the respective protein and/or messenger ribonucleic acid (mRNA) are indicated by red arrows.