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. 2020 Mar 1;12(3):673. doi: 10.3390/nu12030673

Figure 4.

Figure 4

Citrus peel inhibits ER stress and mTORC1 in hyperlipidemic rats. Rats were placed on either an NCD or 60% HFD for eight weeks and were supplemented with ultra-pure water, metformin (100 mg/kg), or one of the indicated concentrations of citrus peel (50 and 100 mg/kg). Immunoblotting using antibodies against p-mTOR, mTOR, p-p70S6K, p70S6K, p-4EBP-1, 4EBP-1, GRP78, CHOP, p-PERK, PERK, p-eIF2α, eIF2α, and β-actin. CPEW, citrus peel extract hot-air dry; CPEF, citrus peel extract freeze-drying; HFD, high-fat diet; NCD, normal calorie diet.