Table 5.
Group (n = 25 per group) and average complete metabolic panel comparisons between Visits 2 and 3.
| 100 mg of DYM | 100 mg of DYM + 50 mg of TCR | 150 mg of DYM + 25 mg of TCR | 150 mg of DYM | Placebo | Average | ||
|---|---|---|---|---|---|---|---|
| Glucose (mg/dL) |
Visit 2 | 87.5 ± 7.2 | 89.1 ± 7.4 | 90.2 ± 5.2 | 91.2 ± 9.4 | 91.0 ± 8.5 | 89.8 ± 7.7 |
| Visit 3 | 87.2 ± 8.5 | 88.2 ± 9.1 | 88.9 ± 6.4 | 91.9 ± 7.6 | 89.9 ± 8.8 | 89.2 ± 8.2 | |
| Blood Urea Nitrogen (mg/dL) |
Visit 2 | 15.2 ± 4.1 | 14.0 ± 4.0 | 14.0 ± 4.6 | 14.2 ± 4.1 | 14.0 ± 3.3 | 14.3 ± 4.0 |
| Visit 3 | 16.5 ± 4.7 | 12.6 ± 3.7# | 14.3 ± 4.9 | 14.0 ± 3.9 | 14.1 ± 2.8 | 14.3 ± 4.2 | |
| Creatinine (mg/dL) |
Visit 2 | 0.984 ± 0.220 | 0.955 ± 0.161 | 0.870 ± 0.191 | 0.947 ± 0.246 | 0.908 ± 0.172 | 0.932 ± 0.201 |
| Visit 3 | 1.003 ± 0.210 | 0.999 ± 0.177 | 0.889 ± 0.198 | 0.981 ± 0.230 | 0.914 ± 0.172 | 0.957 ± 0.200 * | |
| Estimated Glomerular Filtration Rate (mL/min/1.73) |
Visit 2 | 96.6 ± 17.8 | 94.1 ± 26.3 | 107.8 ± 16.7 | 93.3 ± 29.0 | 104.0 ± 14.9 | 99.3 ± 22.0 |
| Visit 3 | 84.1 ± 31.0 | 92.0 ± 15.4 | 105.7 ± 15.4 | 91.6 ± 26.7 | 103.8 ± 16 | 95.5 ± 22.9 * | |
| Blood Urea Nitrogen–Creatinine Ratio | Visit 2 | 16.1 ± 5.0 | 14.8 ± 4.4 | 16.0 ± 4.2 | 14.9 ± 5.4 | 15.3 ± 3.3 | 15.4 ± 4.5 |
| Visit 3 | 16.7 ± 4.2 | 12.9 ± 4.1 | 16.0 ± 4.0 | 14.7 ± 4.1 | 15.5 ± 3.1 | 15.1 ± 4.1 | |
| Sodium (mmol/L) |
Visit 2 | 141 ± 2 | 140 ± 2 | 140 ± 2 | 141 ± 2 | 140 ± 2 | 141 ± 2 |
| Visit 3 | 141 ± 1 | 140 ± 2 | 140 ± 2 | 141 ± 2 | 141 ± 2 | 141 ± 2 | |
| Potassium (mmol/L) |
Visit 2 | 4.80 ± 0.42 | 4.62 ± 0.48 | 4.46 ± 0.44 | 4.98 ± 1.91 | 4.35 ± 0.32 | 4.64 ± 0.95 |
| Visit 3 | 4.61 ± 0.52 | 4.63 ± 0.83 | 4.41 ± 0.29 | 4.64 ± 0.70 | 4.60 ± 0.42 | 4.58 ± 0.59 | |
| Chloride (mmol/L) |
Visit 2 | 102 ± 3 | 101 ± 4 | 102 ± 2 | 103 ± 2 | 102 ± 2 | 102 ± 3 |
| Visit 3 | 103 ± 2 | 103 ± 2 | 102 ± 2 | 103 ± 3 | 103 ± 2 | 103 ± 2 * | |
| Total Carbon Dioxide (mmol/L) |
Visit 2 | 24.3 ± 2.3 | 24.3 ± 2.0 | 23.2 ± 2.5 | 23.4 ± 2.2 | 23.9 ± 2.2 | 23.8 ± 2.2 |
| Visit 3 | 23.2 ± 2.1 | 23.3 ± 1.7 | 22.2 ± 2.3 | 23.2 ± 2.6 | 24.3 ± 2.3 | 23.3 ± 2.3 * | |
| Calcium (mg/dL) |
Visit 2 | 9.64 ± 0.27 | 9.53 ± 0.31 | 9.47 ± 0.37 | 9.32 ± 0.45 | 9.53 ± 0.34 | 9.50 ± 0.37 |
| Visit 3 | 16.77 ± 23.90 | 9.40 ± 0.34 | 9.44 ± 0.29 | 9.44 ± 0.33 | 9.50 ± 0.38 | 10.87 ± 10.77 |
* Significantly (p < 0.05) different from Visit 2. # Significantly (p < 0.05) different from 100 mg of Dynamine on Visit 3.