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The key molecular targets of curcumin linked with inflammation, cell death, and cell proliferation in in vitro and in vivo models of PCa. The sign ⊣ indicated inhibition by curcumin. AR: Androgen receptor signalling; AP-1: Activating protein-1; PI3K/Akt/mTOR: Phosphatidylinositol 3-kinases/the serine/threonine kinase; Wnt/ß: Wingless (Wnt)/ß-catenin signalling, and molecular targets: NF-κB; Nuclear factor kappa-B; Bcl-2: B-cell lymphoma 2 and Cyclin D1.
