. 2007 Sep 2;5:59–112. doi: 10.1016/S1075-8593(06)05002-7

Table 1.

The past, present and future of antiviral drugs (Part II: RNA viruses except retroviruses)

Virus	Compound
	Approved for medical use	In clinical development	In preclinical evaluation
Picorna (Entero, Rhino)	–	Pleconaril	Pyrrolidinyl pentenoic acid (ethyl ester)
		Ruprintrivir	Mycophenolic acid (MPA) mofetil
			Interferon (inducers)

Alpha and Flavi (Yellow fever, Dengue, West Nile, …)	–	–	Triaryl pyrazoline Interferon (inducers)

Hepaci (HCV)	Pegylated interferon-α	BILN 2061 (Ciluprevir)	SCH 446211 (SCH6)
	combined with ribavirin	VX-950 (Telaprevir)	$2^{'}$ -C-methylcytidine
		NM 283 (Valopicitabine)	$2^{'}$ -O-methylcytidine
		Viramidine (Taribavirin)	$2^{'}$ -C-methyladenosine
		SCH 503034	7-Deaza- $2^{'}$ -C-methyladenosine
		DEBIO-025	$2^{'}$ -C-methylguanosine
			$2^{'}$ -Deoxy- $2^{'}$ -fluoro- $2^{'}$ -C-methylcytidine
			$4^{'}$ -Azidocytidine (R1479)
			DKA compd 30
			Benzimidazole derivative
			Benzimidazole 5-carboxamide derivative
			Indole-N-acetamide derivative
			Benzothiadiazine derivative
			Phenylalanine derivative
			Thiophene 2-carboxylic acid derivative
			Dihydropyranone derivative
			Tetrahydropyranoindolyl acetic acid derivative HCV-371
			N-1-Aza-4-hydroxyquinolone benzothiadiazine A-782759

Pesti (BVDV)			VP32947
			Compound 1453
			BPIP
			AG110

Corona (SARS)	–	Pegylated interferon-α (“off label”)	Calpain inhibitors (III, VI) Niclosamide anilide
			Phe–Phe dipeptide
			TG-0205221
			Bananin
			Valinomycin
			Glycyrrhizin
			Chloroquine
			Niclosamide
			Nelfinavir
Orthomyxo (Influenza)	Amantadine	–	RWJ-270201
	Rimantadine		A-192558
	Zanamivir		A-315675
	Oseltamivir		T-705
	Ribavirin (‘off label’)		Flutimide

Paramyxo (Parainfluenza, Measles,	Ribavirin (approved for RSV only)	–	VP-14637 JNJ-2408068
Mumps, RSV, hMPV, …)			BMS-433771
			MBX-300
			A-60444
			Compound D
			YM-53403
			BCX 2798 & BCX-2855

Arena (Lassa, …)	Ribavirin (“off label”)	–	–

Bunya (Crimean–Congo, Rift	Ribavirin (“off label”)	–	–
Valley, …)

Rhabdo (Rabies)	–	–	–

Filo (Ebola, Marburg)	–	–	3-Deazaneplancin A