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. 2020 Apr 9;20:116. doi: 10.1186/s12935-020-01167-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — EZH2 overexpression accelerates oxidative stress in melanoma cells by targeting CDKN1C. a, b, RT-qPCR assay of mRNA expression of EZH2 (a) and CDKN1C (b) in melanoma tissues and adjacent normal tissues. c, d, Western blot assay of protein expression of EZH (c) and CDKN1C (d) in melanoma tissues and adjacent normal tissues. e Survival time analysis by Kaplan–Meier method (n = 75). f Correlation analysis of CDKN1C expression and EZH2 expression. G, Dual-luciferase reporter gene assay of the relationship between EZH2 and CDKN1C. *p < 0.05, compared with the adjacent normal tissues or cells transduced with oe-E-NC. The above measurement data are expressed as mean ± standard deviation. The Paired t-test is adopted to analyze the data of melanoma tissues and adjacent normal tissues, and the unpaired t-test is used for other data comparisons between two groups. Data among multiple groups are analyzed by one-way ANOVA, followed by Tukey’s post hoc test