Table 3.
Descriptive statistics and summary of psychological outcomes of TP53 carriers with a previous cancer diagnosis vs with those who are unaffected
| Scale | Scale range/threshold | Study enrolment | Preresults | 12 weeks after results | 26 weeks after results | 52 weeks after results | |||||
| Previous cancer (n=15) | Unaffected (n=29) | Previous cancer (n=14) | Unaffected (n=22) | Previous cancer (n=9) | Unaffected (n=20) | Previous cancer (n=12) | Unaffected (n=20) | Previous cancer (n=9) | Unaffected (n=19) | ||
| HADS Anxiety, mean (SD); n above threshold | 0–21 | 6.3 (3.6) | 6.1 (4.1) | 5.3 (3.8) | 5.3 (4.0) | 4.9 (4.7) | 6.3 (4.1) | 5.6 (3.8) | 6.1 (4.3) | 5.7 (3.8) | 5.7 (5.3) |
| 0–7 | 10 | 19 | 11 | 18 | 6 | 13 | 8 | 14 | 7 | 12 | |
| 8–10 | 4 | 5 | 1 | 2 | 2 | 3 | 3 | 4 | 1 | 4 | |
| >10 | 1 | 5 | 2 | 2 | 1 | 4 | 1 | 1 | 1 | 3 | |
| HADS Depression mean (SD); n above threshold | 0–21 | 2.1 (2.0) | 2.4 (2.8) | 2.3 (2.9) | 2.5 (2.8) | 1.7 (2.7) | 2.6 (3.6) | 2.8 (3.2) | 2.4 (2.6) | 4.1 (3.9) | 2.5 (3.8) |
| 0–7 | 15 | 27 | 13 | 21 | 8 | 18 | 10 | 18 | 7 | 18 | |
| 8–10 | 0 | 2 | 0 | 0 | 1 | 0 | 2 | 2 | 2 | 0 | |
| >10 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 1 | |
| CWS-R, mean (SD) | 8–32 | 14.2 (2.1) | 14.5 (4.1) | 13.1 (2.6) | 13.8 (5.1) | 13.4 (2.2) | 15.4 (4.9) | 13.0 (2.8) | 15.2 (4.7) | 14.2 (2.1) | 14.5 (4.1) |
| IES: cancer intrusion |
0–35 | – | – | 9.6 (6.7) | 12.6 (10.2)* | 8.6 (9.0) | 8.1 (9.4)* | 8.2 (8.5) | 12.6 (10.7) | 8.1 (8.4) | 9.7 (8.3) |
| 0–8 | 5 | 9 | 5 | 13 | 6 | 8 | 4 | 10 | |||
| >8 | 9 | 13 | 4 | 6 | 5 | 12 | 4 | 9 | |||
| IES: cancer avoidance | 0–40 | – | – | 12.5 (8.6) | 13.8 (11.7) | 9.0 (7.8) | 10.4 (9.7) | 11.5 (11.6) | 14.4 (10.0) | 7.8 (7.2) | 11.1 (10.2) |
| 0–8 | 5 | 7 | 3 | 8 | 6 | 6 | 3 | 8 | |||
| >8 | 9 | 15 | 6 | 11 | 5 | 14 | 5 | 11 | |||
*Significant difference in mean scores between time-points (same group).
CWS-R, Cancer Worry Scale Revised; HADS, Hospital Anxiety and Depression Scale; IES, Impact of Events Scale.