Table 2.
Association between baseline physical activity and risk of dementia
| Model 1a All-cause dementia | Model 2b All-cause dementia | Model 3b Incident cases at the first follow-up visit excluded All-cause dementia | Model 4b Alzheimer’s dementia | Model 5b Incident AD cases at the first follow-up visit excluded Alzheimer’s dementia | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n/N = 117/1550 | n/N = 117/1550 | n/N = 89/1521 | n/N = 79/1511 | n/N = 57/1489 | ||||||
| HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | |
| Household/transportation activities | ||||||||||
| ≤ 1.6 | 1 (Ref) | – | 1 (Ref) | – | 1 (Ref) | – | 1 (Ref) | – | 1 (Ref) | – |
| ]1.6–2.0] | 0.53 [0.34–0.82] | 0.005 | 0.55 [0.35–0.87] | 0.01 | 0.57 [0.34–0.97] | 0.04 | 0.49 [0.28–0.86] | 0.01 | 0.57 [0.29–1.10] | 0.10 |
| > 2.0 | 0.55 [0.34–0.90] | 0.02 | 0.62 [0.38–1.01] | 0.06 | 0.70 [0.40–1.24] | 0.22 | 0.65 [0.36–1.16] | 0.14 | 0.85 [0.43–1.68] | 0.65 |
| Leisure and sport activities | ||||||||||
| None | 1 (Ref) | – | 1 (Ref) | – | 1 (Ref) | – | 1 (Ref) | – | 1 (Ref) | – |
| ]0–8.18] | 1.18 [0.79–1.78] | 0.42 | 1.36 [0.89–2.06] | 0.15 | 1.12 [0.69–1.81] | 0.66 | 1.46 [0.88–2.42] | 0.15 | 1.08 [0.60–1.97] | 0.80 |
| > 8.18 | 1.03 [0.57–1.86] | 0.92 | 1.33 [0.72–2.44] | 0.36 | 1.17 [0.59–2.32] | 0.65 | 1.43 [0.68–3.00] | 0.35 | 1.15 [0.48–2.73] | 0.76 |
n/N = number of cases/total
HR Hazard Ratio, CI Confidence Interval
a Minimally adjusted Cox proportional hazard model: adjusted for age, center, sex, APOE, and education level
b Multi-adjusted Cox proportional hazard model: adjusted for age, center, sex, APOE, education level, living alone, diabetes, depressive symptomatology, cardiovascular disease