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Schematic image of potential molecular mechanisms. Exosomes carrying miR-124-3p derived from BMMSCs enhance M2 macrophage polarization by regulating Ern1, thus alleviating spinal injury in SCIRI. In SCIRI rats, exosomes were derived from BMMSCs expressing miR-124-3p, which elevated Arg1, Ym1, and Fizz expression and promoted M2 macrophage polarization by inhibiting Ern1 expression. Furthermore, exosomal miR-124-3p suppressed cell apoptosis and nerve injury induced by SCIRI
