Table 3.
Detail information of the RIPK1 gene polymorphisms
| SNP | Chromosome | BP | Alleles | Group | Genotype | Allele | MAF | HWE p | HaploReg | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs6907943 | 6 | 3,078,032 | A/C | CC | CA | AA | C | A | Enhancer histone marks, Motifs changed, Selected eQTL hits | |||
| Control | 13 (2.62%) | 129 (25.96%) | 355 (71.42%) | 155 (15.59%) | 839 (84.41%) | 0.156 | 0.734 | |||||
| Case | 15 (4.40%) | 77 (22.58%) | 249 (73.02%) | 107 (15.69%) | 575 (84.31%) | 0.157 | ||||||
| rs2077681 | 6 | 3,085,866 | A/G | CC | CT | TT | C | T | Motifs changed, Selected eQTL hits | |||
| Control | 9 (1.82%) | 140 (28.28%) | 346 (69.90%) | 158 (15.96%) | 832 (84.04%) | 0.160 | 0.313 | |||||
| Case | 19 (5.57%) | 89 (26.10%) | 233 (68.33%) | 127 (18.62%) | 555 (81.38%) | 0.186 | ||||||
| rs9503400 | 6 | 3,108,673 | A/G | AA | AG | GG | A | G | Enhancer histone marks, Motifs changed | |||
| Control | 1 (0.20%) | 47 (9.44%) | 450 (90.36%) | 49 (4.92%) | 947 (95.08%) | 0.051 | 1.000 | |||||
| Case | 3 (0.88%) | 39 (11.40%) | 300 (87.72%) | 45 (6.58%) | 639 (93.42%) | 0.066 | ||||||
| rs17548629 | 6 | 3,114,223 | C/T | TT | TC | CC | T | C | Motifs changed | |||
| Control | 9 (1.81%) | 122 (24.50%) | 367 (73.69%) | 140 (14.06%) | 856 (85.94%) | 0.141 | 0.855 | |||||
| Case | 10 (2.92%) | 72 (21.05%) | 260 (76.03%) | 92 (13.45%) | 592 (86.55%) | 0.134 | ||||||
SNP Sing nucleotide polymorphism, MAF Minor allele frequency, HWE Hardy weinberg equilibrium