Table 4.
The association of RIPK1 gene polymorphisms with cervical cancer susceptibility in Uygur population
| SNP | Model | Allele/Genotype | Frequency (Control/Case) | OR (95%CI) | P Value | FDR-p Value |
|---|---|---|---|---|---|---|
| rs6907943 | Allele | C | 15.59%/15.69% | 1.01 (0.77–1.32) | 0.958 | 0.958 |
| A | 84.41%/84.31% | 1.00 | ||||
| Codominant | CC | 2.62%/4.40% | 1.65 (0.77–3.52) | 0.199 | 0.597 | |
| CA | 25.96%/22.58% | 0.85 (0.61–1.18) | 0.333 | 0.666 | ||
| AA | 71.42%/73.02% | 1.00 | ||||
| Dominant | CC-CA | 28.58%/26.98% | 0.92 (0.68–1.26) | 0.616 | 0.924 | |
| AA | 71.42%/73.02% | 1.00 | ||||
| Recessive | CC | 2.62%/4.40% | 1.72 (0.81–3.65) | 0.162 | 0.597 | |
| CA-AA | 97.38%/95.60% | 1.00 | ||||
| Log-additive | 1.01 (0.78–1.31) | 0.956 | 0.958 | |||
| rs2077681 | Allele | C | 15.96%/18.62% | 1.21 (0.93–1.56) | 0.155 | 0.245 |
| T | 84.04%/81.38% | 1.00 | ||||
| Codominant | CC | 1.82%/5.57% | 3.14 (1.40–7.07) | 0.006 | 0.018 | |
| CT | 28.28%/26.10% | 0.94 (0.69–1.29) | 0.711 | 0.711 | ||
| TT | 69.90%/68.33% | 1.00 | ||||
| Dominant | CC-CT | 30.10%/31.67% | 1.08 (0.80–1.45) | 0.634 | 0.711 | |
| TT | 69.90%/68.33% | 1.00 | ||||
| Recessive | CC | 1.82%/5.57% | 3.20 (1.43–7.16) | 0.005 | 0.018 | |
| CT-TT | 98.18%/94.43% | 1.00 | ||||
| Log-additive | 1.20 (0.93–1.54) | 0.163 | 0.245 | |||
| rs9503400 | Allele | A | 4.92%/6.58% | 1.36 (0.90–2.07) | 0.146 | 0.271 |
| G | 95.08%/93.42% | 1.00 | ||||
| Codominant | AA | 0.20%/0.88% | 4.46 (0.46–43.25) | 0.197 | 0.271 | |
| GA | 9.44%/11.40% | 1.25 (0.79–1.95) | 0.339 | 0.339 | ||
| GG | 90.36%/87.72% | 1.00 | ||||
| Dominant | AA-GA | 9.64%/12.28% | 1.31 (0.85–2.04) | 0.226 | 0.271 | |
| GG | 90.36%/87.72% | 1.00 | ||||
| Recessive | AA | 0.20%/0.88% | 4.36 (0.45–42.26) | 0.203 | 0.271 | |
| GA-GG | 99.8%/99.12% | 1.00 | ||||
| Log-additive | 1.35 (0.89–2.03) | 0.155 | 0.271 | |||
| rs17548629 | Allele | T | 14.06%/13.45% | 0.95 (0.72–1.26) | 0.724 | 0.724 |
| C | 85.94%/86.55% | 1.00 | ||||
| Codominant | TT | 1.81%/2.92% | 1.57 (0.63–3.92) | 0.334 | 0.663 | |
| TC | 24.50%/21.05% | 0.83 (0.60–1.16) | 0.277 | 0.663 | ||
| CC | 73.69%/76.03% | 1.00 | ||||
| Dominant | TT-TC | 26.31%/23.97% | 0.88 (0.64–1.21) | 0.442 | 0.663 | |
| CC | 73.69%/76.03% | 1.00 | ||||
| Recessive | TT | 1.81%/2.92% | 1.64 (0.66–4.07) | 0.289 | 0.663 | |
| TC-CC | 98.19%/97.08% | 1.00 | ||||
| Log-additive | 0.95 (0.72–1.26) | 0.724 | 0.724 |
SNP Sing nucleotide polymorphism, OR Odds ratios, CI Confidence intervals, FDR False discovery ratel
Bold italics indicates the SNP with statistical significance (p < 0.05)