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. 2020 Mar 30;219(4):e201907213. doi: 10.1083/jcb.201907213

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© 2020 Subramanian et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 6. — APC-Cdh1 mediates increased proteolysis with DNA damage. (a) Quantification of cyclin B1-GFP fluorescence decline in Setx^−/−-ON GV-stage oocytes that were either Cdh1 depleted or mock depleted. (b) GVBD rates for Setx^−/−-ON oocytes that were either Cdh1 depleted or mock depleted. (c and d) Quantification of cyclin B1-GFP fluorescence decline in Eto-ON GV-stage oocytes that were either Cdh1 depleted or mock depleted (c) and Eto-ON oocytes that were either DMSO treated (Control) or MG132 treated (d). Oocyte numbers are shown in parentheses from a minimum of three independent experiments. Error bars are mean ± SEM. Two-way ANOVA used for statistical analysis. ****, P < 0.0001.

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