Skip to main content
. Author manuscript; available in PMC: 2020 Apr 10.
Published in final edited form as: Antivir Ther. 2019;24(1):45–50. doi: 10.3851/IMP3277

Table 2.

Average Steady-State Concentrations and Comparative Ratios for Intracellular Analytes, by Regimen and Serostatus. Data are reported as median (25th, 75th percentile). Eight men contributed data to each group. TFV: tenofovir; BP: blood plasma; SP: seminal plasma; AUC: area-under-the-concentration-time curve; TFVdp: tenofovir diphosphate; dATP: deoxyadenosine triphosphate; PBMC: peripheral blood mononuclear cells; SMC: seminal mononuclear cells; Css,ave: average steady-state concentration, calculated as AUC/dosing interval (PBMCs) or reported directly from pooled specimens (SMCs). TAF: Tenofovir alafenamide; TDF: tenofovir disoproxil fumarate. FTC: emtricitabine; FTCtp: emtricitabine triphosphate; dCTP: deoxycytidine triphosphate

TFVdp PBMC
Css, ave
(fmol/ 106 cells)		 TFVdp SMC
Css, ave
(fmol/ 106 cells)		 TFVdp
SMC: PBMC
Css, ave
Ratio		 dATP PBMC
Css,ave
(fmol/ 106 cells)		 dATP SMC
Css, ave
(fmol/ 106 cells)		 dATP
SMC: PBMC
Css, ave
Ratio		 TFVdp:dATP PBMC
Css,ave
ratio		 TFVdp:dATP SMC
Css,ave
ratio
HIV− TDF/ FTC 116 (108, 164) 21 (4.2, 39.3) 0.22 (0.04, 0.32) 123 (111, 140)** 64.6 (3.82, 82.7) 0.54 (0.035, 0.78) 0.96 (0.81, 1.45) 0.656 (0.317, 1.21)
HIV+ TDF/ FTC 192 (156, 237) 21 (6.1, 58) 0.09 (0.04, 0.39) 192 (119, 224) 33.3 (11.6, 55.4) 0.20 (0.054, 0.35) 1.1 (0.86, 1.14) 0.99 (0.43, 1.54)
HIV+ TAF/ FTC 935 (684, 2024)* 35 (24, 78) 0.03 (0.01, 0.07) 184 (138, 262) 43.4 (32.6, 71.1) 0.17 (0.11, 0.35) 5.95 (5.02, 7.34)*** 1.10 (0.42, 1.70)
FTCtp PBMC
Css, ave
(fmol/ 106 cells)		 FTCtp SMC
Css, ave
(fmol/ 106 cells)		 FTCtp
SMC:PBMC
Css, ave
Ratio		 dCTP PBMC Css,ave
(fmol/ 106 cells)		 dCTP SMC
Css, ave
(fmol/ 106 cells)		 dCTP
SMC: PBMC
Css, ave
Ratio		 FTCtp: dCTP PBMC Css,ave
ratio		 FTCtp: dCTP SMC Css,ave
ratio
HIV− TDF/ FTC 6460 (5060, 7837) 88.1 (62.9, 156.7) 0.016 (0.0051, 0.032) 585 (563, 698) 115 (7.5, 224) 0.22 (0.012, 0.29) 10.8 (8.27 (13.4) 1.85 (0.85, 3.31)
HIV+ TDF/ FTC 6397 (5263, 9408) 83.7 (52.5, 137.4) 0.013 (0.0051, 0.020) 590 (462, 825) 71 (34, 107) 0.13 (0.035, 0.17) 10.1 (8.07, 12.5) 1.40 (0.48, 1.82)
HIV+ TAF/ FTC 7756 (7161, 14530) 179 (135, 356) 0.014 (0.011, 0.033) 758 (712, 945) 83 (39, 172) 0.063 (0.044, 0.21) 11.3 (10.4, 12.7) 3.81 (2.30, 3.98)
*

p = 0.004 for comparison to HIV-; p = 0.03 for comparison to HIV+

**

p =0.007 for TDF and TAF comparisons

***

p = 0.001 for comparison to HIV-; p=0.002 for comparison to HIV+