TABLE 4.

Comparison of outcomes

		SD	PD	ORR			SD	PD	ORR
PD-L1+ 1%	% effect	19.9	43.5	18.8	PD-L1+ 10%		11.3	52.2	18.9
	N	499	474	747			251	251	294
	95% CI	10.2–31.9	33.4–53.8	16.1–21.8			3.5–22.8	45.8–58.5	14.6–23.8
PD-L1− 1%	% effect	20.4	52.8	8.8	PD-L1− 10%		22.3	54.3	8.8
	N	81	81	193			88	81	242
	95% CI	12.4–30.7	33.8–81.3	5.3–13.7			14.2–32.2	43.0–65.3	5.6–13.1
Comparison	% Diff	0.5	9.3	10.0	Comparison		11	2.1	8.7
	P value	0.9	0.1	0.0009a			0.01a	0.7	0.003a
PD-L1+ 5%	% effect	9.5	47.8	20.9	PD-L1+ 25%		9	47.8	19.7
	N	184	159	238			159	159	159
	95% CI	5.7–14.7	39.9–55.8	15.9–26.6			5.0–14.5	39.9–55.8	13.8–26.6
PD-L1− 5%	% effect	22.3	54.3	9.2	PD-L1− 25%		18.3	58.8	9
	N	88	81	321			153	146	307
	95% CI	14.2–32.2	43.0–65.3	5.9–13.7			7.9–31.7	50.5–66.8	6.1–12.8
Comparison	% Diff	12.7	6.5	11.7	Comparison		9.3	11	10.7
	P value	0.004a	0.34	0.004a			0.02a	0.05	0.001a
HPV+	% effect	17.8	47.4	21.2	HPV Comparison	% Diff	1.3	2.8	6.2
	N	95	95	193
	95% CI	10.8–26.8	37.2–57.8	15.8–27.6
HPV−	% effect	18.9	50	15		P value	0.8	0.6	0.06
	N	290	290	411
	95% CI	14.6–23.9	44.1–55.9	11.7–18.8
PD-L1+ 1% vs 5%	% Diff	10.4	4.3	2.1	PD-L1+ 5% vs 10%		1.7	4.7	2
	P value	0.001a	0.3	0.5			0.6	0.4	0.6
PD-L1+ 1% vs 10%	% Diff	8.6	8.7	0.05	PD-L1+ 5% vs 25%		0.5	6.5	1.2
	P value	0.003a	0.03a	1.0			0.9	0.3	0.8
PD-L1+ 1% vs 25%	% Diff	10.9	4.4	0.9	PD-L1+ 10% vs 25%		0.8	4.4	0.8
	P value	0.002a	0.3	0.8			0.8	0.4	0.8

Abbreviations: ORR, overall response rate; PD, progressive disease; SD, stable disease.

^aSignificant difference.