Table 2.

The General Linear Models (with sigma-restricted parametrization) results with the two (age, sex) predictors and age-sex interaction.

	Medians [mL]		Age predictor		Sex predictor		Age × Sex interaction		Full model
GLM Models	Males	Females	β*	p-value	β**	p-value	β***	p-value	p-value
GM	722.9	645.3	$-0.4834$	$<0.001$	$0.919$	$<0.001$	-0.4153	$0.0974$	$<0.001$
WM	539.6	456.1	0.1228	0.1092	0.5496	0.0365	0.1848	$0.4827$	$<0.001$
CSF	267.0	241.2	$0.3517$	$<0.001$	$0.8535$	$0.0093$	-0.5335	$0.1044$	$<0.001$
THA L	6.471	5.745	$-0.3032$	$<0.001$	$0.9303$	$0.0012$	-0.3956	$0.1632$	$<0.001$
THA R	6.360	5.637	$-0.3775$	$<0.001$	$0.7835$	$0.0049$	-0.2728	$0.3242$	$<0.001$
PUT L	3.925	3.602	$-0.2836$	$0.002$	0.3996	0.1921	0.0607	$0.8442$	$<0.001$
PUT R	3.974	3.553	-0.1571	0.0847	0.3332	0.2815	0.185	$0.554$	$<0.001$
CAU L	2.617	2.488	$-0.4143$	$<0.001$	-0.098	0.7647	0.2525	$0.4467$	$<0.001$
CAU R	2.749	2.663	$-0.3525$	$<0.001$	-0.1396	0.6783	0.3048	$0.372$	$<0.001$
HIP L	2.698	2.667	-0.0279	0.794	0.3766	0.3035	-0.1872	0.6126	0.25
HIP R	2.749	2.703	-0.1565	0.1329	0.4955	0.1628	-0.2454	0.493	0.0172
AMY L	0.983	0.979	0.0178	0.8686	0.5431	0.1414	-0.4372	0.2413	0.3927
AMY R	1.001	0.925	-0.07	0.5022	0.639	0.0749	-0.3867	0.2845	0.0316
PAL L	1.448	1.308	0.1225	0.2206	0.0631	0.8527	0.3605	$0.296$	$<0.001$
PAL R	1.539	1.333	0.1829	0.0535	0.272	0.3959	0.25	$0.4408$	$<0.001$
ACC L	0.398	0.341	-0.2137	0.0305	0.2448	0.4623	0.1225	$0.7161$	$<0.001$
ACC R	0.324	0.260	-0.1926	0.0467	0.1798	0.5824	0.2316	$0.4845$	$<0.001$

The results marked in red are statistically significant with p < 0.0146.

^*The sign (+/-) of β for the age predictor - means the increasing/decreasing brain structure volume with age.

^**The sign (+/-) of β for the sex predictor - means the higher/lower brain structure volumes for the males.

^***The sign (+/-) of β for the age-sex interaction - means the increasing/decreasing male/female brain.

structure volume ratios with age.